Direct Synthesis of Amides Without the Waste

Researchers at the Weizmann Institute of Science (Rehovot, Israel) say they have developed a clean, direct synthesis of amides that could potentially be applied to fine chemicals and pharmaceuticals. Most routes to amides use toxic reagents such as carboxylic acid chlorides, require corrosive acid or base activators, and generate toxic chemical waste. The key to the new process is a ruthenium (Ru) complex-based catalyst, which contains a dearomatized pyridine ligand bound to a tertiary amine ligand, say the researchers, who published their work in a recent issue...

This information is only available to Chemical Week subscribers.

Forgot your user ID or password?
Click here to have it sent to you.

Email Address First Name Last Name

Not an IHS Chemical Week 24/7 member yet? Here's why you should be: Searchable online archive access of the last 2 years of Chemical Week. Print or digital magazine subscription Price and market change alerts Economic data and statistics Buyers' Guides Webcasts | whitepapers