Chemical Week Magazine :: Other
Direct Synthesis of Amides Without the Waste
11:57 AM MDT | September 14, 2007 | Michelle Bryner
Researchers at the Weizmann Institute of Science (Rehovot, Israel) say they have developed a clean, direct synthesis of amides that could potentially be applied to fine chemicals and pharmaceuticals. Most routes to amides use toxic reagents such as carboxylic acid chlorides, require corrosive acid or base activators, and generate toxic chemical waste. The key to the new process is a ruthenium (Ru) complex-based catalyst, which contains a dearomatized pyridine ligand bound to a tertiary amine ligand, say the researchers, who published their work in a recent issue...
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