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How did Venter create a synthetic genome?

11:28 AM MST | December 10, 2010 | —laura Templer

To create the world’s first synthetic microorganism - a synthetic bacteria - scientists at the J. Craig Venture Institute (JCVI; San Diego, CA) first designed 1,078 specific cassettes of DNA by synthesizing single base pairs and assembling them using a computer. A cassette is a sequence of DNA encoding one or more genes for a single biotechnical function. The ends of each cassette overlapped by 80 basepairs in order for them all to “stick” together into one single genome. The whole genome is then placed inside a host bacteria or “chassis.” In Venter’s...

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