Chemical Week Magazine :: Cover Story
How did Venter create a synthetic genome?
11:28 AM MST | December 10, 2010 | â€”laura Templer
To create the worldâ€™s first synthetic microorganism - a synthetic bacteria - scientists at the J. Craig Venture Institute (JCVI; San Diego, CA) first designed 1,078 specific cassettes of DNA by synthesizing single base pairs and assembling them using a computer. A cassette is a sequence of DNA encoding one or more genes for a single biotechnical function. The ends of each cassette overlapped by 80 basepairs in order for them all to â€śstickâ€ť together into one single genome. The whole genome is then placed inside a host bacteria or â€śchassis.â€ť In Venterâ€™s...
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