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EFSA panel concludes that 3-acetyl-2,5-dimethylthiophene is genotoxic

8:25 AM MDT | May 17, 2013 | Michael Ravenscroft

The European Food Safety Authority (EFSA; Parma, Italy) has concluded that 3-acetyl-2,5-dimethylthiophene, used as a flavoring additive in food, is mutagenic in vitro and in vivo, and that its use as a flavoring substance raises a safety concern. The decision is based on new data from a bacterial gene-mutation assay and an in vivo study on mice. Genotoxic substances should not be intentionally added to the food chain. EU risk managers will now decide whether to remove 3-acetyl-2,5-dimethylthiophene from the EU list of authorized flavoring substances. The...

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